synthesis and antihypertensive activity of novel 4-[1-(4-x-benzyl)-5-imidazolyl] dihydropyridines in rat
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abstract
a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipine. the most active compound (5e) had fluorine substituent (x=f).
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The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. Primarily pharmacological studies of the title co...
full textsynthesis of 4-(1-benzyl-5-imidazolyl)-1,4-dihydropyridines
the o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. primarily pharmacological studies of the title co...
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full textEffects of 4-(2-Alkylthio-1-benzyl-5-imidazolyl)-Dihydropyridines on the Isolated Rat Colon and Right Atrium Contractility
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full textsynthesis of novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] dihydropyridines and studying their effects on rat blood pressure
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full textSynthesis of Novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] Dihydropyridines and Studying their Effects on Rat Blood Pressure
OBJECTIVES Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel 1, 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. MATERIALS AND METHODS Four 1, 4-dihydropyridi...
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research in pharmaceutical sciencesجلد ۲، شماره ۲، صفحات ۸۵-۰
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